Pesquisa | BVS IEC

1.

High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota.

Lee, Jee-Yon; Tiffany, Connor R; Mahan, Scott P; Kellom, Matthew; Rogers, Andrew W L; Nguyen, Henry; Stevens, Eric T; Masson, Hugo L P; Yamazaki, Kohei; Marco, Maria L; Eloe-Fadrosh, Emiley A; Turnbaugh, Peter J; Bäumler, Andreas J.

Cell ; 187(5): 1191-1205.e15, 2024 Feb 29.

Artigo em Inglês | MEDLINE | ID: mdl-38366592

2.

An antibiotic from an uncultured bacterium binds to an immutable target.

Shukla, Rhythm; Peoples, Aaron J; Ludwig, Kevin C; Maity, Sourav; Derks, Maik G N; De Benedetti, Stefania; Krueger, Annika M; Vermeulen, Bram J A; Harbig, Theresa; Lavore, Francesca; Kumar, Raj; Honorato, Rodrigo V; Grein, Fabian; Nieselt, Kay; Liu, Yangping; Bonvin, Alexandre M J J; Baldus, Marc; Kubitscheck, Ulrich; Breukink, Eefjan; Achorn, Catherine; Nitti, Anthony; Schwalen, Christopher J; Spoering, Amy L; Ling, Losee Lucy; Hughes, Dallas; Lelli, Moreno; Roos, Wouter H; Lewis, Kim; Schneider, Tanja; Weingarth, Markus.

Cell ; 186(19): 4059-4073.e27, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37611581

3.

High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients.

Nguyen, Chi L; Markey, Kate A; Miltiadous, Oriana; Dai, Anqi; Waters, Nicholas; Sadeghi, Keimya; Fei, Teng; Shouval, Roni; Taylor, Bradford P; Liao, Chen; Slingerland, John B; Slingerland, Ann E; Clurman, Annelie G; Maloy, Molly A; Bohannon, Lauren; Giardina, Paul A; Brereton, Daniel G; Armijo, Gabriel K; Fontana, Emily; Gradissimo, Ana; Gyurkocza, Boglarka; Sung, Anthony D; Chao, Nelson J; Devlin, Sean M; Taur, Ying; Giralt, Sergio A; Perales, Miguel-Angel; Xavier, Joao B; Pamer, Eric G; Peled, Jonathan U; Gomes, Antonio L C; van den Brink, Marcel R M.

Cell ; 186(12): 2705-2718.e17, 2023 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-37295406

4.

Structural Mimicry in Microbial and Antimicrobial Amyloids.

Golan, Nimrod; Engelberg, Yizhaq; Landau, Meytal.

Annu Rev Biochem ; 91: 403-422, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35729071

5.

Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection.

Nick, Jerry A; Dedrick, Rebekah M; Gray, Alice L; Vladar, Eszter K; Smith, Bailey E; Freeman, Krista G; Malcolm, Kenneth C; Epperson, L Elaine; Hasan, Nabeeh A; Hendrix, Jo; Callahan, Kimberly; Walton, Kendra; Vestal, Brian; Wheeler, Emily; Rysavy, Noel M; Poch, Katie; Caceres, Silvia; Lovell, Valerie K; Hisert, Katherine B; de Moura, Vinicius Calado; Chatterjee, Delphi; De, Prithwiraj; Weakly, Natalia; Martiniano, Stacey L; Lynch, David A; Daley, Charles L; Strong, Michael; Jia, Fan; Hatfull, Graham F; Davidson, Rebecca M.

Cell ; 185(11): 1860-1874.e12, 2022 05 26.

Artigo em Inglês | MEDLINE | ID: mdl-35568033

6.

Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.

Hayase, Eiko; Hayase, Tomo; Jamal, Mohamed A; Miyama, Takahiko; Chang, Chia-Chi; Ortega, Miriam R; Ahmed, Saira S; Karmouch, Jennifer L; Sanchez, Christopher A; Brown, Alexandria N; El-Himri, Rawan K; Flores, Ivonne I; McDaniel, Lauren K; Pham, Dung; Halsey, Taylor; Frenk, Annette C; Chapa, Valerie A; Heckel, Brooke E; Jin, Yimei; Tsai, Wen-Bin; Prasad, Rishika; Tan, Lin; Veillon, Lucas; Ajami, Nadim J; Wargo, Jennifer A; Galloway-Peña, Jessica; Shelburne, Samuel; Chemaly, Roy F; Davey, Lauren; Glowacki, Robert W P; Liu, Chen; Rondon, Gabriela; Alousi, Amin M; Molldrem, Jeffrey J; Champlin, Richard E; Shpall, Elizabeth J; Valdivia, Raphael H; Martens, Eric C; Lorenzi, Philip L; Jenq, Robert R.

Cell ; 185(20): 3705-3719.e14, 2022 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-36179667

7.

A selective antibiotic for Lyme disease.

Leimer, Nadja; Wu, Xiaoqian; Imai, Yu; Morrissette, Madeleine; Pitt, Norman; Favre-Godal, Quentin; Iinishi, Akira; Jain, Samta; Caboni, Mariaelena; Leus, Inga V; Bonifay, Vincent; Niles, Samantha; Bargabos, Rachel; Ghiglieri, Meghan; Corsetti, Rachel; Krumpoch, Megan; Fox, Gabriel; Son, Sangkeun; Klepacki, Dorota; Polikanov, Yury S; Freliech, Cecily A; McCarthy, Julie E; Edmondson, Diane G; Norris, Steven J; D'Onofrio, Anthony; Hu, Linden T; Zgurskaya, Helen I; Lewis, Kim.

Cell ; 184(21): 5405-5418.e16, 2021 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-34619078

8.

Bifidobacteria-mediated immune system imprinting early in life.

Henrick, Bethany M; Rodriguez, Lucie; Lakshmikanth, Tadepally; Pou, Christian; Henckel, Ewa; Arzoomand, Aron; Olin, Axel; Wang, Jun; Mikes, Jaromir; Tan, Ziyang; Chen, Yang; Ehrlich, Amy M; Bernhardsson, Anna Karin; Mugabo, Constantin Habimana; Ambrosiani, Ylva; Gustafsson, Anna; Chew, Stephanie; Brown, Heather K; Prambs, Johann; Bohlin, Kajsa; Mitchell, Ryan D; Underwood, Mark A; Smilowitz, Jennifer T; German, J Bruce; Frese, Steven A; Brodin, Petter.

Cell ; 184(15): 3884-3898.e11, 2021 07 22.

Artigo em Inglês | MEDLINE | ID: mdl-34143954

9.

The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination.

Wimmers, Florian; Donato, Michele; Kuo, Alex; Ashuach, Tal; Gupta, Shakti; Li, Chunfeng; Dvorak, Mai; Foecke, Mariko Hinton; Chang, Sarah E; Hagan, Thomas; De Jong, Sanne E; Maecker, Holden T; van der Most, Robbert; Cheung, Peggie; Cortese, Mario; Bosinger, Steven E; Davis, Mark; Rouphael, Nadine; Subramaniam, Shankar; Yosef, Nir; Utz, Paul J; Khatri, Purvesh; Pulendran, Bali.

Cell ; 184(15): 3915-3935.e21, 2021 07 22.

Artigo em Inglês | MEDLINE | ID: mdl-34174187

10.

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.

Greene, Brandon L; Kang, Gyunghoon; Cui, Chang; Bennati, Marina; Nocera, Daniel G; Drennan, Catherine L; Stubbe, JoAnne.

Annu Rev Biochem ; 89: 45-75, 2020 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-32569524

11.

A Deep Learning Approach to Antibiotic Discovery.

Stokes, Jonathan M; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M; MacNair, Craig R; French, Shawn; Carfrae, Lindsey A; Bloom-Ackermann, Zohar; Tran, Victoria M; Chiappino-Pepe, Anush; Badran, Ahmed H; Andrews, Ian W; Chory, Emma J; Church, George M; Brown, Eric D; Jaakkola, Tommi S; Barzilay, Regina; Collins, James J.

Cell ; 180(4): 688-702.e13, 2020 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-32084340

12.

The Science of Antibiotic Discovery.

Lewis, Kim.

Cell ; 181(1): 29-45, 2020 04 02.

Artigo em Inglês | MEDLINE | ID: mdl-32197064

13.

Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.

Hayes, Beth M; Radkov, Atanas D; Yarza, Fauna; Flores, Sebastian; Kim, Jungyun; Zhao, Ziyi; Lexa, Katrina W; Marnin, Liron; Biboy, Jacob; Bowcut, Victoria; Vollmer, Waldemar; Pedra, Joao H F; Chou, Seemay.

Cell ; 183(6): 1562-1571.e12, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33306955

14.

Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.

Tuganbaev, Timur; Mor, Uria; Bashiardes, Stavros; Liwinski, Timur; Nobs, Samuel Philip; Leshem, Avner; Dori-Bachash, Mally; Thaiss, Christoph A; Pinker, Elisha Y; Ratiner, Karina; Adlung, Lorenz; Federici, Sara; Kleimeyer, Christian; Moresi, Claudia; Yamada, Takahiro; Cohen, Yotam; Zhang, Xiao; Massalha, Hassan; Massasa, Efi; Kuperman, Yael; Koni, Pandelakis A; Harmelin, Alon; Gao, Nan; Itzkovitz, Shalev; Honda, Kenya; Shapiro, Hagit; Elinav, Eran.

Cell ; 182(6): 1441-1459.e21, 2020 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-32888430

15.

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis.

Winkler, Emma S; Shrihari, Swathi; Hykes, Barry L; Handley, Scott A; Andhey, Prabhakar S; Huang, Yan-Jang S; Swain, Amanda; Droit, Lindsay; Chebrolu, Kranthi K; Mack, Matthias; Vanlandingham, Dana L; Thackray, Larissa B; Cella, Marina; Colonna, Marco; Artyomov, Maxim N; Stappenbeck, Thaddeus S; Diamond, Michael S.

Cell ; 182(4): 901-918.e18, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32668198

16.

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.

Martin, James K; Sheehan, Joseph P; Bratton, Benjamin P; Moore, Gabriel M; Mateus, André; Li, Sophia Hsin-Jung; Kim, Hahn; Rabinowitz, Joshua D; Typas, Athanasios; Savitski, Mikhail M; Wilson, Maxwell Z; Gitai, Zemer.

Cell ; 181(7): 1518-1532.e14, 2020 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-32497502

17.

Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning.

Nielsen, Jens.

Cell ; 177(6): 1373-1374, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31150617

18.

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action.

Yang, Jason H; Wright, Sarah N; Hamblin, Meagan; McCloskey, Douglas; Alcantar, Miguel A; Schrübbers, Lars; Lopatkin, Allison J; Satish, Sangeeta; Nili, Amir; Palsson, Bernhard O; Walker, Graham C; Collins, James J.

Cell ; 177(6): 1649-1661.e9, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31080069

19.

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.

Hagan, Thomas; Cortese, Mario; Rouphael, Nadine; Boudreau, Carolyn; Linde, Caitlin; Maddur, Mohan S; Das, Jishnu; Wang, Hong; Guthmiller, Jenna; Zheng, Nai-Ying; Huang, Min; Uphadhyay, Amit A; Gardinassi, Luiz; Petitdemange, Caroline; McCullough, Michele Paine; Johnson, Sara Jo; Gill, Kiran; Cervasi, Barbara; Zou, Jun; Bretin, Alexis; Hahn, Megan; Gewirtz, Andrew T; Bosinger, Steve E; Wilson, Patrick C; Li, Shuzhao; Alter, Galit; Khurana, Surender; Golding, Hana; Pulendran, Bali.

Cell ; 178(6): 1313-1328.e13, 2019 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-31491384

20.

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Lin, Jinzhong; Zhou, Dejian; Steitz, Thomas A; Polikanov, Yury S; Gagnon, Matthieu G.

Annu Rev Biochem ; 87: 451-478, 2018 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-29570352

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Instituto Evandro Chagas

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